Additional outpatient therapeutics for the COVID toolkit–what I learned from Drs. Ryan Cole, Robert Malone and Richard Urso this weekend. I will be adding to this list as I learn more

Old standbys (which I have used and can vouch for):

Ivermectin 0.4-0.6 mg/kg daily for 5 days dependiong on how sick you are and which variant you experience, take with food with fat

Hydroxychloroquine 200 mgx2 breakfast and lunch day one, then 200 mg 2x daily for 6 more days. Take with or before food

Doxycycline 100 mg 2x/day with large meal, avoid sun for a week or azithromycin 250 mg 2 on day 1, then 1 daily for 4 more days or a little longer

Aspirin 325 mg/day helps block blood clotting throughits inhibition of platelet activation.  Some people who form clots anyway may benefit from additional blood thinners targeting other clotting mechanisms, such as lovenox.

Vitamin D–try to achieve a blood level of 60 which should reduce risk for all respiratory illneses and likely other medical conditions

Vitamin C up to 1000mg 3 or 4 times daily

Zinc 30-60 mg daily

Melatonin 3-12 mg at bedtime

For early lung problems within the first week:  inhaled albuterol and dexamethazone cheapest to buy as vials to use with a nebulizer.  

Newer approaches that can be added to the old or substituted (but I have not used all of them and there are no published protocols)

After one week of illness you take steroids (prednisone or methylprepdnisolone or others) orally, about 40-60 mg/day for continuing lung problems and inflammation that occurs throughout the body.

For mast cell/allergy syndrome, use (OTC) both H1 and H2 blockers.  Recommended are Pepcid 40-80 mg 3 times daily and cyproheptadine (Periactin) 6 mg 3x daily, which also blocks the serotonin response. 

Anti-androgens also have efficacy.  FLCCC suggests you use both spironolactone and dutasteride or finasteride. 

Celebrex (celecoxib) plus pepcid is another good combination

Metformin 500 mg once daily reduces high insulin levels and high blood sugar. https://c19early.com/mf

N-acetyl cysteine 500 mg 2x/day will help mop up the debris caused by inflammation. OTC and still available, though FDA proposes to take it off OTC status.

Tricor (aka fenofibrate) 145 mg per day helps break down infiltrates containing a lot of lipids via emulsification and lets your body heal quicker from cytokine storm.

Fluconazole–mentioned by Ryan Cole, and beneficial when there is a Candida albicans secondary infection.  I don’t have any evidence it works as a direct treatment for coronaviruses.

Colchicine– https://c19colchicine.com/

Fluvoxamine– https://c19fluvoxamine.com/

Bromhexine seems to be a good drug, but not available in the US. https://c19bromhexine.com/ May be OTC in countries where available.

Various anticancer drugs and antipsychotic drugs–only for life-threatening cases–kill coronaviruses in the early stage of illness but can have significant side effects

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Anonymous
Anonymous
8 months ago

Great list, from some of the greats…

Anonymous
Anonymous
8 months ago

Dr Nass, where is the break between the old standbys and the new ones that you've added? Thanks.

Anonymous
Anonymous
8 months ago

I believe that Ambroxol is the primary "metabolite" of Bromhexine. Ambroxol can be purchased on Amazon.

I have seen information that both drugs are TMPRSS2 inhibitors, which means that they inhibit the membrane fusion route of viral entry into the cell. I believe that the other main route, less important, is endosomal entry, which is inhibited by HCQ. Combining the two has been called "dual-entry inhibition" and gives much better results during viral replication than HCQ alone. There are other TMPRSS2 inhibitors, including but not limited to bromelain (which sounds etymologically related to bromhexine, of course).

Quercetin and bromelain are available in combined form. I don't know whether quercetin inhibits endosomal entry, but it does have in common with HCQ that it is a zinc ionophore, which inhibits viral replication in another way. A much more bio-available form of quercetin than the usual stuff is quercetin physosome. That is available on its own, and also combined with bromelain, from Thorne Research. When combined with bromelain, the Thorne product is called "Quercenase".

Here is a study showing the success of dual-entry inhibition (in which a different TMPRSS2 inhibitor was used):

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009212

– posted by Moki

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