Theoretically better. Based on antigens and titers. Not on cases and cases prevented:
The FDA approved the first three-antigen hepatitis B vaccine (PreHevbrio) to prevent infection from all known subtypes in adults, VBI Vaccines announced on Wednesday.
Approval for the recombinant vaccine — which contains the S, pre-S1, and pre-S2 hepatitis B virus (HBV) surface antigens — was based on data from two phase III trials that compared the safety and immunogenicity against the single-antigen Engerix-B vaccine.
In PROTECT, the three-antigen vaccine demonstrated higher seroprotection rates versus Engerix-B among all adults (91% vs 77%, respectively) and among those 45 and older (89% vs 73%). In CONSTANT, a pooled analysis of adults who received PreHevbrio had numerically higher seroprotection rates compared to the Engerix-B group (99% vs 95%).
As I showed recently , there is no demonstrated increase of Hepatitis B in the US, according to CDC, only estimates of a potential problem.
Given the massive increase in iv drug abuse since 2009, I would have expected an increase in new Hepatitis B infecctions, but CDC did not produce any evidence that there is one. But if you are monogamous or not sexually active, and don’t use dirty needles, the chance of getting Hepatitis B is close to zero.
Will these be the next mandated vaccines?